Bioactivities of Alchemilla mollis, Alchemilla persica and Their Active Constituents

The aim of this study was to determine antimicrobial activities Alchemilla mollis, persica as well ellagic acid and miquelianin against Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans by using microbroth dilution method anti-inflammatory activity human red blood cell (HRBC) membrane stabilization method. Microbroth used the activities. Extracts possessed having MIC values 2.5-5-10mg/ mL, compounds 1.25-2.5-4-5mg/mL. A.mollis aerial parts displayed highest (IC50=1.22±0.07mg/mL). Ellagic were also determined agents with 0.57±0.01mg/mL 1.23±0.02mg/mL IC50 values, respectively. Total phenolic content tannin A.persica 357.00±75.80mg, 282.50±28.70mg PGE/g plant material 18.02%, 18.63% respectively according described European Pharmacopoeia. acid, catechin analyzed HPLC. detected in roots (6.69±0.05g/100g material). contain higher (0.39±0.02g/plant material) (1.56±0.01g/ than A.persica.